Author index

Abe, M. 30

Acton, R.T. 166 Ahrén, B. 333 Akanuma, Y. 44 Albarran, R.de 89 Alberti, K.G.M.M. 392, 420 Albrecht, G. 315 Amorosa, L.F. 355 An, T. 449 Andersen, A.R. 361 Aro, A. 453

Artal, R. 65

Asmal, A.C. 20 Asp, N.-G. 272 Asplin, C.M. 203 Assal, J.-Ph. 255

Baba, S. 379 Bach, F.H. 415 Baird, H.R. 127 Baldissera, F.G.A. 223 Balkau, B. 39 Barbosa, J. 170, 415 Barger, B.O. 166 Barr, D. 266 Barradas, M.A. 89 Barry, P.J. 173 Baynes, J.W. 93 Becker, K. 282 Bennett, 127 Bennion, L.J. 127 Berger, M. 441 Betterle,C. 431 Billaudel, B. 76 Birtwell, A.J. 261 Boberg, M. 272 Bompiani,G.D. 426 Bonde-Petersen, F. 328 Bottazzo,G.F. 241 Boulton, A.J.M. 15 Bretzel, R.G. 169 British Multicentre Study Group 109 Bruining, G.J. 24 Bruining, H.A. 24 Budowle, B. 166 Burge, C.T.R. 261 Burnstock, G. 81 Businger, J. 278 Byrne, E. 250

Cagliero, E. 218 Campbell, I.W. 437 Capito, K. 375 Cerasi, E. 142, 146 Chavers, B. 415 Chisholm, D.J. 208 Christensen, N.J. 328 Clarke, B.F. 437 Cobelli, C. 314 Colle, E. 310 Collier,G. 50 Cook, D. 420 Corrall, R.J.M. 445 Corrigan, C.B. 333

Creutzfeldt, W. 441 Crockett, M. 81 Cudworth, A.G. 15

Damoiseaux, P. 255 Dandona, P. 89 Davidson, M.B. 473 Davies, C.J. 261 Deckert, T. 361 Deleers, M. 55 Dornan, T.L. 199 Douglas, C.A. 266 Drury, J. 15 Duner, E. 314 Dyrberg, T. 159

Ebert, R. 441 Eichler, H.G. 278 Eisele, S.G. 60 Ejiri, K. 379 Elliott, R.B. 297 Engle, M.J. 60 Enzmann, F. 169 Eriksson, C.J.P. 34 Etzwiler, D. 415

Falt, K. 282

Falkmer, S. 282 Farrell, P.M. 60 Faure, A. 76 Federlin, K. 169 Feingold, K.R. 234 Fischer, U. 315 Flock, E.V. 127 Foster, D.M. 349 Foulis, A.K. 456 Francis, A.J. 420 Franetzki, M. 169 French, R.R. 466 Frenckell, R. von 229 Frokjzr Thomsen, O. 361 Fujii, S. 379

Gagliardino, J.J. 290 Galluzzo, A. 426 Gambhir, K.K. 89 Gasic, S. 278 Gechter, F. 150 Gelsthorpe, K. 266 Genovese, S. 116 Gepts, W. 282 Giordano, C. 426 Girard, J. 103

Go, R.C.P. 166 Goldstein, D.E. 214 Gomez Dumm,C.L. 290 Gragnoli,G. 411 Green, A. 190, 195 Greniman, M. 328 Greten, H. 366 Groop, L. 34 Gustafsson, I.-B. 272

Hadden, D.R. 250 Haring, H.U. 462 Haffner, S.M. 349 Hage, C. 142 Hagura,R. 44 Hahn, C. 255 Hammond, M.G. 20 Hanning, I. 266, 420 Hansen, B. 169 Hansen, J.A. 199 Harano, Y. 343 Hardisty,C.A. 15 Hari, J. 379

Harley, J.M.G. 250 Hashimoto, N. 449 Hasslacher, Ch. 150 Haven, A.J. 81 Hazzard, W.R. 349 Hedeskov, C.J. 375 Heding, L.G. 261 Heine, R.J. 420 Hellerstrém, C. 393 Hellqvist, L.N.B. 370 Henriksen, T. 218 Hernandez, R.E. 290 Heyburn, P. 261 Hidaka, H. 343 Hillson, R.M. 6, 122 Hilsted, J. 328 Hockaday, T.D.R. 6, 122 Hollander, P.M. 203 Holst, J.J. 223 Hougaard, P. 190 Howell, S.L. 319 Hutson, J.C. 155 Hutton, R.A. 89 Huupponen, R. 34 Hyosu, T. 343

Ikeda, Y. 30 Imamura, Y. 379 Ishihara, K. 379 Ito, H. 134

Jarrett, R.J. 99, 401 Joffe, S. 65 Johansen, K. 180, 406 Johnston, C. 1 Jones, 1.R. 261 Jovanovic, L. 214 Jutzi, E. 315

Kadowaki, T. 44 Kahn, C.R. 229 Kajinuma, H. 44 Kanatsuka, A. 449 Karlstrém, B. 272 Kashiwagi, A. 343 Kataoka, K. 30 Kazumi, T. 379 Keen, H. 401 Keller, U. 103 Kemmler, W. 462 Kemnitz, J.W. 60 Kennedy, L. 93

475 Kerner, W. 169 Khachadurian, A.K. 355 King, H. 39 Kirsch, D. 462

Kohner, E.M. 173 Korhonen, T. 453 Korn, A. 278 Kosaka, K. 44 Kosugi, K. 343 Kraegen, E.W. 208 Krone, W. 366 Kiihn-Velten, N. 300 Kuntschen, F. 255 Kushwaha, R.S. 349 Kuzuya, N. 44

Lager, 1. 337 Larkins, R.G. 304 Lear, S.R. 234 Lernmark, A. 159 Levy, J. 142 Lewin, 1.G. 445 Lincoln, J. 81 Lindeman, J. 24 Lindsay, K.A. 60 Lithell, H. 272 Lorup, B. 180 Lorenzi, M. 218 Ludvigsson, J. 138 Luzio, S. 261

Mackintosh, D. 401 Makino, H. 449 Malaisse, W.J. 55 Mancini, M. 116 Mari, A. 314 Markey, B. 218 Marliss, E.B. 159 Marner, B. 24 Martin, J.M. 297 Maruyama, T. 30 Massi Benedetti, M. 169 Mastranzo, P. 116 Mathiesen, E.R. 406 Matsuba, I. 30 Matsuki, S.. 30 McAuley, R.R. 250 McClure, G. 250 McCulloch, D.K. 437 McLean, A. 50 Michael, A.F. 415 Miyake, Y. 44 Molenaar, J. 24 Mollo, F. 314 Monciotti, C.M. 431 Morgan, M.H. 445 Morita, I. 134 Moser, A.H. 234 Miintefering, H. 282 Murota,S. 134

Nagulesparan, M. 127 Nakhooda, F. 159 Navalescu, I. 169 Nerurkar, S.G. 89

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476

Nesher, R. 142, 146 Newton, D.J. 122 Niederau, C. 441 Norgaard, M.-B. 328 Nosadini, R. 314

@rskov, H. 420 O'Brian, I1.A.D. 445 O’Dea, K. 50 Omar, M.A.K. 20 Osegawa, M. 449 Owens, D.R. 261 Oxenboll, B. 406

Pacioni, D. 116 Palmer, J.P. 199, 203 Parving, H.-H. 328 Pedini, B. 431 Pelkonen, R. 34 Penttila, I. 453 Perelman, R.H. 60 Pernet, A. 255, 420 Peterson, C.M. 214 Pfeiffer, E.F. 169 Pirson, W. 278 Ponchner, M. 420 Poussier, P. 159 Prescott, R.J. 437 Presotto, F. 431 Pyke, D.A. 1

Raghu, P.K. 199 Rahier, J. 282 Raper, L.R. 39 Rapp, L.B. 431

Raptis, S. 169

Raskin, P. 214

Re, C.A. 304 Rebolledo, O.R. 290 Reeves, W.G. 266 Reichenbacher, R. 150 Renold, A.E. 255 Rhodes, C.J. 370 Riccardi,G. 116 Rich, S. 170

Rigon, F. 431 Rinninger, F. 462 Rivellese, A. 116 Roberts, A.P. 389 Roseman, J.M. 166 Rubino, G. 426 Ruderman, N.B. 355 Ryall, R.G. 389

Saito, Y. 134 Salzsieder, E. 315 Sampietro, T. 218

Sandahl Christiansen, J. 361

Sandler, S. 386 Sarlund, H. 453 Savage, P.J. 127 Schenck, H. von 337 Schermer, R. 300 Schneider, S.H. 355 Schnell, H. 103 Seemayer, T.A. 310 Semino, M.C. 290 Shamoon, H. 183 Sherwin, R. 183 Shigeta, Y. 343 Shii, K. 379 Siegel, E. 441

Signorini, A.M. 411 Sims, E.A.H. 88 Skene, A. 266

Smith, U. 337 Sodoyez-Goffaux, F. 229 Sodoyez, J.C. 229 Solander, F. 195 Sperling, M.A. 65 Spiro, M.J. 70

Staib, W. 300

Starke, A. 441 Stauffacher, W. 103 Stewart, J.A. 456

Story, C.J. 389 Stremmel, W. 441 Strohmeyer, G. 441 Sutter, B.Ch.J. 76 Suzuki, M. 328, 343 Suzuki, T. 449 Svendsen, P.Aa. 180, 406

Takahashi, R. 134 Takaku, F. 44 Takei, I. 30 Tanganelli, I. 411 Taniguchi, H. 379 Taniyama, M. 30 Tattersall, R.B. 266 Taylor, K.W. 370 Taylor, R. 392 Thams, P. 375 Timpl, R. 150 Treves, S. 229 Trimble, E.R. 255 Trotter, I. 250

Tsuruoka, A. 30 Tuch, B. 142

Tuk, C.W. 24 Tuunainen, A. 453

Uno, S. 343 Uusitupa, M. 453

Vasquez, B. 127 Veroni, M.C. 304 Vessby, B. 272 Viberti,G. 401

Waldhausl, W. 12, 169 Waldman, L. 146 Ward, J.D. 15 Weinberg, C.R. 199 Wells, L. 266 Werner, I. 272 Werther, G.A. 65 Wiles, P.G. 1 Wilson, R.M. 266 Wiseman, M. 401 Witztum, J.L. 218 Wolf, E. 15 Worth, R.C. 15

Yaso, S. 379

Ylikahri, R. 34 Yokono, K. 379 York, D.A. 466 Young, R.J. 437

Zanette, F. 431 Zimmet, P. 39

HEE

Subject index

Key: c=correspondence, r= review

A cell, pancreatic — glucose regulation 203

Adenine nucleotide metabolism in diabetes 89c

Adenylate cyclase - enhancing factor from mouse pancreas 375

— regulation in adipocyte membrane — ob/ob mice 466

Adrenergic innervation — diabetic rat 81

AIDSPIT - workshop report 169

Albumin deposition — in dermal capillary basement membrane 415

Aldose reductase inhibitor — in symptomatic diabetic neuropathy 445

a-amylase inhibitor — effect on post-prandial glucose 278

Androgen binding protein — streptozotocin diabetes — rat 300

Apolipoprotein B — catabolism in Type 1 diabetes 349

Arachidonic acid — platelet phospholipid — Type 2 diabetes 134

Artificial insulin delivery systems — workshop 169

Artificial pancreas — see glucose clamp

p-adrenergic blockade — Type 1 diabetes 183

B-cell damage in diabetic insulitis 241 r

— function — insulin antibodies in diabetic children 138

— function - review 393r

Basement membrane collagen - UDP-ga- lactose — diabetic rat 70

— glomerular — type IV collagen — rats 150

British multicentre study group — proliferative retinopathy — Xenon arc 109

Calcium — distribution in B cells 290

Chiorpropamide - it’s role in determining CPAF 34

Chlorpropamide alcohol flush —- see CPAF

Cholesterol synthesis — Chinese hamsters — ob/ob mice — db/db mice 234

Cholinergic innervation — diabetic rat 81

Coronary artery disease — Type 2 diabetes 99r

CPAF - a critical reappraisal 6r

— role of chlorpropamide, alcohol and acetaldehyde 34

— to flush or not to flush? 12r

— the case in favour 1r

CSII - kinetic modelling studies 208

Diet — cereal fibre in Type 2 diabetes 272

Dietary fibre — and carbohydrate — metabolic control in diabetes 116

— protein — a trigger of insulin-dependent diabetes in BB rat 297

Dimethyl urea — protection against hyperglycaemia 386

Epidemiology — diabetes in Tanzania 333

— impaired glucose tolerance in Naura 39

— mortality in insulin-treated diabetes — Denmark 190

— use of hospital services by insulin-treated diabetics 195

Erythrocyte 2,3-bisphosphoglycerate in Type 1 diabetes 389

Exercise - control in Type 2 diabetes 355

Exocrine pancreas -— autopsy findings in Type 1 diabetes 456

Experimental diabetes — glomerular vasement membrane - type IV collagen 150

Factors governing the human immune response to injected insulin 266 Fibre, cereal — Type 2 diabetes 272

Gastrin response — in patients with vagal neuropathy 445

GIP - effect of fat and carbohydrate ingestion on response 50

Gliquidone — extrapancreatic actions — rat 462

Glucagon deficiency associated with hypoglycaemia 473 c

— infusion — in Type 1 diabetes 337

— related peptides in the human gastrointestinal mucosa 223

Glucose clamp — and manual technique for assessing insulin sensitivity 420

Glucose tolerance — natural history in Naura 39

- risk factors for worsening to diabetes 44

Glucose utilization — opiates — dog 65

Glycosuria — renal threshold in Type 1 diabetes 180

Glycosylation, non-enzymic — chronic diabetic complications 93 r

Growth hormone - ketone body kinetics 103

Guar gum - metabolic response in Type 2 diabetes 453

Haemoglobin, glycosylated — evaluation of assays 214

HLA-A, B, C and D in South African blacks — Type 1 diabetes 20

— seasonal patterns of diagnosis of Type 1 diabetes 199

How does glucose regulate the human pancreatic A cell in vivo? 203

Human endothelial cells — interaction with LDL and glucose 218

Hyperinsuli ia — non-cirrhotic haemochromatosis 441

Hyperproinsulinaemia in cirrhosis 392

Hypoglycaemia — f-adrenergic blockade in Type 1 diabetes 183

— insulin induced — haemodynamic changes in normal man 328

— persistent neonatal — B and D cells 282

Immune response to injected insulin 266

Impotence — natural history in diabetic men 437

Insulin action — opiates modulate in dogs 65

— antibodies -— B cell function in diabetic children 138

— degradation - impaired in non-cirrhotic haemochromatosis 441

— internalization in human erythrocytes 89c

477

— receptor - in vivo imaging and quantitative analysis 229

— regulation of sterol synthesis 366

— release - sulphonylurea binding — artificial phospholipid layer 55

— -— suppression of arginine effect by

hyperglycaemia 142

— resistance — insulin concentration in Type 1 diabetes 255

— secretion — a review 319r

— — adrenal interference after oestradiol

treatment 76

— - calcium distribution in B cells 290

— — islet-activating protein 304

— sensitivity - and co-ingestion of fat and carbohydrate 50

Insulin, isophane — studies in normal subjects 261

Insulin, subcutaneous — estimated absorption using mathematical model 315c¢

— reply from the authors 315¢

Insulinitis — autopsy findings in newly diagnosed Type 1 diabetes 456

Islet activating protein — insulin secretion — NZO mouse 304

Islet cell antibody — review 241r

— time course and characteristics — childhood diabetes 24

Islet cell surface antibody — cell mediated cytotoxicity to human pancreatic B cell 30

— precede spontaneous diabetes in BB rat 159

Islet transplantation — workshop 169

Ketone bodies — in Type 1 diabetes 343

LDL, native and glycosylated — interaction with human endothelial cells 219

Lipolysis — ketone body kinetics and growth hormone 103

Lymphocyte antibody — precede spontaneous diabetes in BB rat 159

Mechanism of insulin secretion 319r

Menstrual cycie — changes in food intake — diabetic Rhesus monkey 60

Monoclonal antibody to islet cell surface antigens 379

Natural history of impotence in diabetic men 437

Nephropathy, diabetic — incipient in Type 1 diabetes 406

— long-term Type 1 diabetes 361

Neuropathy, autonomic

— early hormonal changes - rat 81

— impotence in diabetic men 437

— vagus and gastrin response 445

Neuropathy — genetic and metabolic studies

15

— use of aldose reductase inhibitor 445

— vibration sense and hyperglycaemia 122

Non-enzymic glycosylation and the chronic complications of diabetes 93r

NPH insulin — studies in normal subjects 261

478

Oestradiol treatment — adrenal interference of insulin secretion 76

Opiates - modulaticn of insulin action - dogs 65

Organ specific auto-immunity — in Type 1 diabetic families 431

Paediatric immunology 316

Pancreatic B cell — life story of 393r

Pancreatic cellular infiltrates - New Zealand black mice 310

Photocoagulation — prevention of blindness 173r

— Xenon arc in proliferative retinopathy 109

Pregnancy, diabetic - changes in food intake — Rhesus monkey 60

Prevention of blindness in diabetic retinopathy 173r

Proteinuria — sustained reduction in Type 2 diabetes 127

Renal threshold — for glucose in Type 1 diabetes 180

Retinopathy, proliferative — photocoagulation using Xenon arc 109

— prevention of blindness 173r

Sertoli cells — altered response under similated diabetic condition 155

Sorbibil — use in diabetic neuropathy 445

Subcutaneous insulin infusion — kinetic modelling studies 208

Sugar nucleotides — effect of diabetes — rat 70

— binding to an artificial phospholipid layer 55

Sulphonylurea — extrapancreatic actions of Gliquidone 462

T lymphocyte subset — in newly diagnosed Type 1 diabetes 426

Time-dependent inhibition of insulin release 142, 146

Trestatin — a-amylase inhibitor 278

Type 1 diabetes — apolipoprotein catabolism 349

— arterial pressure and micro-albuminuria 401

— auto-immunity in probands and relatives 431

— autopsy results on newly diagnosed children 456

— P-adrenergic blockade 183

— cell-mediated cytotoxic islet cell surface antibody 30 complement component C4 in black Americans 166 deposition of albumin in dermis 415 erythrocyte 2,3-biphosphoglycerate 389 genetic heterogeneity 170c glucagon infusion 337 glycosylation of urinary proteins 411 health of children of diabetic mothers 250 HLA heterogeneity and season 199 HLA in South African blacks 20 incipient nephropathy 406 insulin resistance and plasma insulin concentration 255 insulitis 241r

Subject index

— ketone bodies as markers 343

- monoclonal antibody probe - mouse 379

— nephropathy 361

— newly diagnosed, and T subset lymphocyte deficiency 426

— renal threshold for glucose 180

Type 2 diabetes —- arachidonic acid and platelet phospholipid 134

— coronary artery disease — chicken or egg! 99r

- effect of a-amylase inhibitor 278

— exercise and control 355

— hyperglycaemia and vibration sense 122

— metabolic response to breakfast and guar gum 453

— progression from glucose intolerance 44

- proteinuria reduction and hyperglycaemia 127

— UK therapy study 88¢

Type IV collagen — and glomerular basement membrane - rats 150

UDP-galactose — diabetes — rat 70

Urinary albumin excretion — Type 1 diabetes 401

Urinary protein glycosylation — Type 1 diabetes 411

Viruses — diabetes and encephalomyocarditis virus 370

Workshop report — artificial insulin delivery systems 169 — pancreas and islet transplantation 169

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